KPV 10mg

Tripeptide fragment of α-MSH.

Identity
Sequence: Lys-Pro-Val (KPV)
CAS: 67727-97-3
Molecular formula: C16H30N4O4
Purity: ≥99% (HPLC)
Form: sterile lyophilised powder
Presentation: 3 mL vial

Research literature
Research on KPV (Lys-Pro-Val) investigates the C-terminal tripeptide fragment of α-melanocyte-stimulating hormone. In-vitro studies characterise its inhibition of NF-κB activation and pro-inflammatory cytokine signalling, and in-vivo work in murine colitis models examines its uptake via the PepT1 di/tripeptide transporter and effects on intestinal inflammation in DSS- and TNBS-induced disease. Subsequent animal studies further investigate the PepT1/KPV axis in the context of colitis-associated tumour development.

References

1. Dalmasso G et al. (2008). PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. PMID 18061177.
2. Viennois E et al. (2016). Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of the anti-inflammatory PepT1-mediated tripeptide KPV in a murine model. Cellular and Molecular Gastroenterology and Hepatology. PMID 27458604.

Documentation
Batch Certificate of Analysis (HPLC, third-party) provided for the lot shipped.

Handling (research)
Store lyophilised cold and protected from light. Reconstitute according to the researcher’s own laboratory procedure.

For Research Use Only. Not for Human or Veterinary Use. Not a drug, food, or supplement; not evaluated by the FDA; not intended for human or animal use.